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Within a latest review, we documented the identification as well as characterization of a fresh atypical opioid receptor with exclusive detrimental regulatory Homes towards opioid peptides.1 Our effects confirmed that ACKR3/CXCR7, hitherto called an atypical scavenger receptor for chemokines CXCL12 and CXCL11, is usually a wide-spectrum scavenger f

Gene expression Examination unveiled that ACKR3 is highly expressed in various brain regions equivalent to critical opioid action centers. Furthermore, its expression concentrations in many cases are increased than These of classical opioid receptors, which more supports the physiological relevance of its noticed in vitro opioid peptide scavenging